|
Diagnosis |
Disease Stage |
Clinical Symptoms |
Neurological Signs |
Standard Therapy |
Experimental Therapy |
|
DSP |
Late |
· Distal Symmetrical numbness, tingling, and burning sensations · Paresthesias or aching |
· Stocking-Glove sensory loss · Depressed or absent ankle reflexes |
· Neurotoxin withdrawal · Analgesics · topical agents · Anticonvulsants · Tricyclic antidepressants · Acupuncture |
· rhNGF · Lidoderm (5% Lidocaine Gel) · Prouridine |
|
IDP |
Early >> Late |
· Progressive weakness · Paresthesias |
· Muscle weakness · Mild sensory loss · Areflexia |
· Corticosteroids · Plasmapheresis · High-Dose Intravenous Immunoglobulin · Ganciclovir, Foscarnet, Cidofovir (Late Stage in HIV Disease) |
NONE |
|
MM |
Early (Limited) Late (Progressive) |
· Foot or wrist drop · Facial Weakness · Focal Pain |
· Multifocal cranial and Peripheral neuropathies |
· Early: None · Late: Ganciclovir, Foscarnet and Cidofovir (singly or in combination) |
NONE |
|
PP |
Late |
· Lower extremity weakness · Sphincter Dysfunction · Paresthesias |
· Flaccid Paraparesis · Saddle Distribution Anesthesia · Depressed ankle and knee reflexes |
· Ganciclovir, Foscarnet and Cidofovir (singly or in combination) |
NONE |
|
AN |
Late >> Early |
· Orthostatic Dizziness · Syncope · Diarrhea · Anhidrosis · Palpitations · Impotence · Urinary Dysfunction |
· Orthostatic Hypotension · Pupillary abnormalities · sweating dysfunction · Resting Tachycardia |
· Discontinuation of offending drugs · Fluorocortisone · Antiarrhythmic agents · Fluid and Electrolyte Replacement |
NONE |