|
Clustering of Th cell epitopes on exposed regions of HIV envelope despite defects in antibody activity Doherty PC, et al.
Journal of Immunology
2003, 171: 4140-4148
Link Here, they tested the hypothesis that Abs on B cell surfaces selectively bind and protect exposed protein fragments during Ag processing, and that this interaction helps to shape the Th cell repertoire. The results clearly demonstrate that normal Ab activity is not required for the establishment or maintenance of Th peptide immunodominance in the HIV envelope response. To explain the clustering of Th cell epitopes, they propose that localization of peptide on exposed envelope surfaces facilitates proteolytic activity and preferential peptide shuttling through the Ag processing pathway.
—Posted: November 11, 2003
More journal headlines: This month | Last month | Search archive
|
