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Productive HIV infection of resting CD41 T cells: Role of lymphoid tissue microenvironment and effect of immunomodulating agents Kinter A, et al.
AIDS Research and Human Retroviruses
19 (10): 847-856 OCT 2003
Link Here, they utilized a tonsillar histoculture system to demonstrate that HIV, particularly X4 strains, can productively infect phenotypically resting CD4(+) T cells in vitro and that this event is largely dependent on the lymphoid tissue microenvironment. The ability of resting CD4(+) T cells to support HIV replication in the microenvironment of the lymphoid tissue has implications in the pathogenesis of HIV disease and may provide an additional avenue for therapeutic intervention.
—Posted: November 7, 2003
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