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March 12, 2010
 
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Last Month's Journal Headlines
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Note: For details on a journal headline, click on the title
Vaccines:
Modified Vaccinia Virus Ankara (MVA) priming and Fowlpox Virus booster elicit stronger CD8+ T cell response in mice against an HIV-1 epitope than DNA-Poxvirus prime-booster approach. Biotechnology and Applied Biochemistry.
The HIV-1 chimeric protein CR3 expressed by poxviral vectors induces a diverse CD8+ T cell response in mice and is antigenic for PBMCs from HIV+ patients. Vaccine.
The first generation of candidate HIV-1 vaccines can induce antibodies able to neutralize primary isolates in assays with extended incubation phases. Vaccine.
Therapeutic vaccination with MVA-HIV-1 nef elicits Nef-specific T-helper cell responses in chronically HIV-1 infected individuals. Vaccine.
Development of a DNA vaccine designed to induce cytotoxic T lymphocyte responses to multiple conserved epitopes in HIV-1. Journal of Immunology.
M cell DNA vaccination for CTL immunity to HIV. Journal of Immunology.
Toll-like receptor ligands modulate dendritic cells to augment cytomegalovirus- and HIV-1-specific T cell responses. Journal of Immunology.
Clustering of Th cell epitopes on exposed regions of HIV envelope despite defects in antibody activity. Journal of Immunology.
Immunization with Th-CTL fusion peptide and cytosine-phosphate-guanine DNA in transgenic HLA-A2 mice induces recognition of HIV-infected T cells and clears vaccinia virus challenge. Journal of Immunology.
Gradual adaptation of HIV to human host populations: good or bad news?. Nature Medicine.
Microparticles and nanoparticles as delivery systems for DNA vaccines. Crit. Rev. Ther. Drug. Carrier Syst..
Peptide immunogens based on the envelope region of HIV-1 are recognized by HIV/AIDS patient polyclonal antibodies and induce strong humoral immune responses in mice and rabbits. Molecular Immunology.
Attenuated nef DNA vaccine construct induces cellular immune response: role in HIV-1 multiprotein vaccine. Immunology Letters.
Safety evaluation of GX-12, a new HIV therapeutic vaccine: Investigation of integration into the host genome and expression in the reproductive organs. Intervirology.
Effector HIV-specific cytotoxic T-lymphocyte activity in long-term nonprogressors: Associations with viral replication and progression. Journal of Medical Virology.
Enhanced immunogenicity of SIV Gag DNA vaccines encoding chimeric proteins containing a C-terminal segment of Listeriolysin O. Virus Research.
Gp120-alum boosting of a Gag-Pol-Env DNA/MVA AIDS vaccine: Poorer control of a pathogenic viral challenge. AIDS Research and Human Retroviruses.
IL-12/GM-CSF coadministration in an SIV DNA prime/protein boost protocol enhances Gag-specific T cells but not virus-specific neutralizing antibodies in rhesus macaques. AIDS Research and Human Retroviruses.
Phenotypic and functional T-cell aging in rhesus macaques (Macaca mulatta): differential behavior of CD4 and CD8 subsets. Blood.
Complexes of plasmid DNA with basic domain 47-57 of the HIV-1 Tat protein are transferred to mammalian cells by endocytosis-mediated pathways. Journal of Biological Chemistry.

Prevention:
Diverse HIV-1 subtypes and clinical, laboratory and behavioral factors in a recently infected US military cohort. AIDS.
Tuberculosis epidemics driven by HIV: is prevention better than cure?. AIDS.
Alternatives to HIV-1 RNA concentration and CD4 count to predict mortality in HIV-1-infected children in resource-poor settings. The Lancet.
Short-term risk of disease progression in HIV-1-infected children receiving no antiretroviral therapy or zidovudine monotherapy: a meta-analysis. The Lancet.
Use of injections in healthcare settings worldwide, 2000: literature review and regional estimates. British Medical Journal.
Human immunodeficiency virus retesting during pregnancy: costs and effectiveness in preventing perinatal transmission. Obstetrics and Gynecology.
Potential use of safer injecting facilities among injection drug users in Vancouver's Downtown Eastside. Canadian Medical Association Journal.
Estimating the cumulative number of human immunodeficiency virus diagnoses by cross-linking from four different sources. Pezzotti P, et al..
Mobility and the spread of human immunodeficiency virus into rural areas of West Africa. International Journal of Epidemiology.
High human immunodeficiency virus type 1 seroprevalence in men who have sex with men in Buenos Aires, Argentina: risk factors for infection. International Journal of Epidemiology.
The impact of behavioural changes on the prevalence of human immunodeficiency virus and hepatitis C among injecting drug users. International Journal of Epidemiology.
Developmental toxicology studies of WHI-07, a novel nucleoside analogue-based dual-function microbicide, administered intravaginally to rabbits. Toxicologic Pathology.
Decline in mortality, AIDS, and hospital admissions in perinatally HIV-1 infected children in the United Kingdom and Ireland. British Medical Journal.
Use of dried whole blood spots to measure CD4+ lymphocyte counts in HIV-1-infected patients. The Lancet.

NeuroAIDS:
HIV-1 Tat protein upregulates inflammatory mediators and induces monocyte invasion into the brain. Molecular and Cellular Neuroscience.
Neuroprotective activities of sodium valproate in a murine model of human immunodeficiency virus-1 encephalitis. Journal of Neuroscience.
Temporal relationships between HIV-1 Tat-induced neuronal degeneration, OX-42 immunoreactivity, reactive astrocytosis, and protein oxidation in the rat striatum. Brain Research.
Cytomegalovirus glycoprotein B genotypes and central nervous system disease in AIDS patients. Journal of Medical Virology.
The primary phase of infection by pathogenic simian-human immunodeficiency virus results in disruption of the blood-brain barrier. AIDS Research and Human Retroviruses.
High frequency of virus-specific CD8+ T cells in the central nervous system of macaques chronically infected with simian immunodeficiency virus SIVmac251. Journal of Virology.
Human immunodeficiency virus type 1 enters primary human brain microvascular endothelial cells by a mechanism involving cell surface proteoglycans independent of lipid rafts. Journal of Virology.
Genetic and functional analysis of full-length human immunodeficiency virus type 1 env genes derived from brain and blood of patients with AIDS. Journal of Virology.

Virology:
Kinetics of lymphocyte proliferation during primary immune response in macaques infected with pathogenic SIVmac251: Preliminary report of the effect of early antiviral therapy. Journal of Virology.
Binding of human immunodeficiency virus type 1 to immature dendritic cells can occur independently of DC-SIGN and mannose binding C-type lectin receptors via a cholesterol-dependent pathway. Journal of Virology.
Quantitation of HLA class II protein incorporated into human immunodeficiency type 1 virions purified by anti-CD45 immunoaffinity depletion of microvesicles. Journal of Virology.
HIV-1 subtype B' dictates the AIDS epidemic among paid blood donors in the Henan and Hubei provinces of China. AIDS.
Increased association of 7SK snRNA with Tat cofactor P-TEFb following activation of peripheral blood lymphocytes. AIDS.
The Tat protein of the human immunodeficiency virus type 1 (HIV-1) interacts with the EGF-like repeats of the Notch proteins and the EGF precursor. Virus Research.
HIV-1 in genital tract and plasma of women: Compartmentalization of viral sequences, coreceptor usage, and glycosylation. Proc. Natl. Acad. Sci. USA.
Identification of T cell-signaling pathways that stimulate latent HIV in primary cells. Proc. Natl. Acad. Sci. USA.
The di-leucine motif in the cytoplasmic tail of CD4 is not required for binding to human immunodeficiency virus type 1 Nef, but is critical for CD4 down-modulation. Journal of General Virology.
Two novel fully functional isoforms of CX3CR1 are potent HIV coreceptors. Journal of Immunology.
Impaired TCR-mediated induction of Ki67 by naive CD4+ T cells is only occasionally corrected by exogenous IL-2 in HIV-1 Infection. Journal of Immunology.
Signaling but not trafficking function of HIV-1 protein Nef is essential for Nef-induced defects in human intrathymic T-cell development. Blood.
Segregation of human immunodeficiency virus type 1 subtypes by risk factor in Australia. Journal of Clinical Microbiology.
Specific HIV-1 env gene silencing by small interfering RNAs in human peripheral blood mononuclear cells. Gene Therapy.
Productive HIV infection of resting CD41 T cells: Role of lymphoid tissue microenvironment and effect of immunomodulating agents. AIDS Research and Human Retroviruses.
Inhibition of HIV-1 infection by a CCR5-binding cyclophilin from Toxoplasma gondii. Blood.
The -1030/-862-linked TNF promoter single-nucleotide polymorphisms are associated with the inability to control HIV-1 viremia. Immunogenetics.
Pro-apoptotic activity of HIV-1 auxiliary regulatory protein Vpr is subtype-dependent and potently enhanced by nonconservative changes of the leucine residue at position 64. Journal of Biological Chemistry.
The enzymatic activity of CEM15/Apobec-3G is essential for the regulation of the infectivity of HIV-1 virion but not a sole determinant of its antiviral activity. Journal of Biological Chemistry.
Functional evolution of the HIV-1 envelope glycoprotein 120 association site of glycoprotein 41. Journal of Biological Chemistry.
Presence of host ICAM-1 in human immunodeficiency virus type 1 virions increases productive infection of CD4+ T lymphocytes by favoring cytosolic delivery of viral material. Journal of Virology.
Inhibition of human immunodeficiency virus type 1 replication in primary macrophages by using Tat- or CCR5-specific small interfering RNAs expressed from a lentivirus vector. Journal of Virology.
Structure and function of CC-chemokine receptor 5 homologues derived from representative primate species and subspecies of the taxonomic suborders Prosimii and Anthropoidea. Journal of Virology.
Contrasting use of CCR5 structural determinants by R5 and R5X4 variants within a human immunodeficiency virus type 1 primary isolate quasispecies. Journal of Virology.
Relationship between in vitro human immunodeficiency virus type 1 replication rate and virus load in plasma. Journal of Virology.
Atomic force microscopy investigation of human immunodeficiency virus (HIV) and HIV-infected lymphocytes. Journal of Virology.

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