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Vol. 3, No. 19, 26 September 2003
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Other Issues:
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AIDScience Perspective:
HIV and hepatitis C epidemics in Africa: continuing the debate
Supporters of the dominant view that the HIV burden in sub-Saharan Africa is driven by heterosexual transmission argue that unsafe health care is not an important factor, because if that were the case, the epidemiologic patterns of HIV and HCV should be similar. Potterat et al. maintain that the principal weakness of this argument lies with the assumption that the two viruses have similar parenteral transmission.
— By John J. Potterat et al.
AIDScience Report:
Recent trends in HIV prevalence among pregnant women in sub-Saharan Africa
There are huge differences in HIV prevalence between African countries, striking sub-regional patterns can be observed and the gap between the sub-regions appears to be widening.— By J. Ties Boerma et al.
[About AIDScience articles] [See recent AIDScience articles]
Hot News:
2004 International HIV/AIDS Training Program
The International Society for Infectious Diseases (ISID) has announced the International HIV/AIDS Training Program for 2004 (April 26-May 7). The purpose of this program is to acquaint health care providers from developing countries and countries-in-transition with state-of-the-art epidemiological, clinical, therapeutic, and public health issues relevant to the rapidly evolving field of HIV/AIDS care. Deadline: February 1, 2004.
NeuroAIDS: HIV-induced metalloproteinase processing of the chemokine stromal cell derived factor-1 causes neurodegeneration
This study identifies a new in vivo neurotoxic pathway in which cleavage of a chemokine by an induced metalloproteinase results in neuronal apoptosis that leads to neurodegeneration. Nature Neuroscience 6(10), 1064, October 2003.
Subpopulations of long-lived and short-lived T cells in advanced HIV-1 infection
First quantitative evidence that long-lived and quiescent T cells do indeed predominate in the T cell pool in humans and determine T cell pool size, as in rodents. The greatest impact of advanced HIV-1 infection is to reduce the generation of long-lived, potential progenitor T cells. Journal of Clinical Investigation 112(6), 956, September 2003.
From Medscape: Antiretroviral drugs and the prevention of sexual transmission of HIV
Practical HIV prevention methods go beyond behavioral interventions. Proper management of HIV and HSV-2 infections might also help slow the HIV epidemic. Medscape HIV/AIDS 9(2), 2003 (Medscape requires a one-time free registration).
NIAID awards $81 million for HIV vaccine development
The U.S. National Institute of Allergy and Infectious Diseases (NIAID) announced four new contracts to support development of candidate HIV vaccines. Each team (AlphaVax Human Vaccines, Epimmune, Novavax, and Progenics Pharmaceuticals) is pursuing a unique vaccine strategy, and these strategies include DNA vaccines, virus vector vaccines, subunit vaccines and virus-like particle vaccines.
AIDS Vaccine 2003 Conference
Access to conference abstracts and posters, updated as of September 23.
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