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Vol. 3, No. 5, 14 March 2003
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Other Issues:
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AIDScience Perspective:
Neutralizing antibody response to HIV and virus escape. Despite an early and effective neutralizing antibody defense, initial infecting viruses are able to mutate rapidly into resistant viruses, escaping neutralization by antibodies.
By Roberto Fernandez-Larsson.
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From Science:
CLINICAL RESEARCH: AIDS vaccine results draw investor lawsuits. VaxGen, the Brisbane, California, biotech that came under scientific fire last month when it revealed results of the first-ever real-world trial of an AIDS vaccine, is now dodging legal bullets.
By Jon Cohen.
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Hot News:
HIV in central and eastern Europe. During the past 5 years, most countries of the former Soviet Union have been severely affected by HIV epidemics that continue to spread as a result of injecting drug use. Eastern Europe will soon be confronted with a major AIDS epidemic.
Lancet, 361, 1035, 22 March, 2003 [Read article]
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Neutralizing antibody response and virus escape. Two papers examine how antibodies quickly eliminate neutralization-sensitive HIV in early infection, only to be replaced by populations of resistant virus. One of the teams discovered that the glycan moieties of env change rather than protein epitopes in yet another mechanism of viral escape.
Nature 422, 307, 20 March 2003 [Read abstract]
Proc. Natl. Acad. Sci. USA, published online 18 March, 2003 [Read abstract]
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