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From Science: Spread of HTLV-I between lymphocytes by virus-induced polarization of the cytoskeleton. Cell contact rapidly induces polarization of the cytoskeleton of the infected cell to the cell-cell junction. HTLV-I core (Gag protein) complexes and the HTLV-I genome accumulate at the cell-cell junction and are then transferred to the uninfected cell. Other lymphotropic viruses, such as HIV-1, may similarly subvert normal T-cell physiology to allow efficient propagation between cells. By Tadahiko Igakura et al. [Free full text article] [About AIDScience articles] [See recent AIDScience articles] [dEbates: Submit a response to this article]

AIDScience Perspective: Topical microbicide prevents HIV transmission. New research published in Nature Medicine demonstrated that a microbicide containing the human monoclonal antibody b12, that binds to the viral gp120, could effectively protect monkeys against the simian-human immunodeficiency virus (SHIV).  [Free full text article]

Hot News: AIDS, HIV up in U.S. for first time in decade. Reports of new HIV infections, along with cases of AIDS, have risen in the United States for the first time in a decade, U.S. health officials told the 10th Annual Conference on Retroviruses and Opportunistic Infections, being held in Boston. Yahoo! News, 11 February 2003 [Read article]

From Medscape's Journal Partners: Immunotherapy for AIDS virus infections: Cautious optimism for cell-based vaccine. Experiments on macaques suggest that injections of modified dendritic cells might boost immunity to hold back disease progression in patients already infected with HIV. Nature Medicine 9(1), 13, January 2003 [Read article] (one-time registration required) See also the scientific article: Nature Medicine 9(1), 27, January 2003 [Read article] (one-time registration required)

HIV/STD risks in young MSM who do not disclose their sexual orientation—Six U.S. cities, 1994-2000. Young men who have sex with men (MSM) who do not disclose their sexual orientation (nondisclosers) are thought to be at particularly high risk for HIV infection. To better understand the prevention needs of young MSM, the U.S. CDC analyzed data from the Young Men's Survey to compare HIV/STD risk differences between nondisclosers and disclosers. This report summarizes the results of that analysis. Morbidity and Mortality Weekly Report 52(05), 81, 7 February 2003 [Read article]

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