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AIDScience Perspective: From Science: HIV/AIDS: Malawi: A suitable case for treatment by Jon Cohen. [Full text article]  [About AIDScience articles]  [See recent AIDScience articles] [See other Cohen articles]  [dEbates: Submit a response to this article]

Hot News: Could widespread use of combination antiretroviral therapy eradicate HIV epidemics? Using uncertainty analysis, a new model predicts that current combination antiretroviral therapies could eventually eradicate the HIV epidemic. The probability was even better if risky sexual behavior was reduced. Lancet Infectious Diseases 2(8), 1 August 2002 [Read paper] Related article: Number-crunching suggests AIDS could die out in San Francisco. San Francisco Chronicle, 1 August 2002 [Read article]

Molecular epidemiology of HIV-1 genetic forms and its significance for vaccine development and therapy. Twenty-four circulating genetic forms of the main HIV-1 group have been recognized, including 11 subtypes or sub-subtypes and 13 circulating recombinant forms, but the significance of these genetic forms for vaccine design and new therapeutic strategies has not been defined. Lancet Infectious Diseases 2(8), 1 August 2002 [Read abstract] (full paper requires registration)

Gene transfer of human monoclonal antibodies generates neutralizing activity against HIV-1 in serum. A recombinant adeno-associated virus (rAAV) vector was used to deliver the gene for the human antibody IgG1b12 to mouse muscle. Significant levels of HIV-neutralizing activity were found in the sera of mice for over 6 months after a single intramuscular administration of the rAAV vector. Journal of Virology 76(17), September 2002 [Read abstract] (full paper requires registration)

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