Other Issues:

AIDScience Perspective: Eat your corn flakes — and get vaccinated? Interview with John Howard from ProdiGene, a company that is developing an edible HIV vaccine.  [Full text article]  [About AIDScience articles]  [See recent AIDScience articles]

Hot News: Reduction of mother to child HIV-1 transmission. Introduction of short-course regimens to prevent mother-to-child transmission of HIV-1 in less-developed countries should be accompanied by interventions to minimise the risk of subsequent transmission via breastfeeding. Lancet 359, 1178 (2002). [Go to free paper]

NeuroAIDS: Progression of HIV-Associated Dementia Treated With HAART. In a study of 96 patients with HIV-associated dementia treated with HAART, of 30 patients meeting the inclusion criteria with adequate follow-up, 60% improved neurologically and 40% progressed. Improvement was associated with plasma viral suppression, whereas progression was strongly associated with injection drug use history (see related study below). AIDS Reader 12(2) (2002). [Go to paper] (Free registration required)

NeuroAIDS: HIV in the CNS: still a cause for concern? Studies in Edinburgh have shown that HIV encephalitis was much more common in drug uses (60%) than in homosexual men (15%) with AIDS, which may be caused by drug use induced activation of microglia. Presented at the Society for General Microbiology meeting in Warwick, England, 8-12 April 2002.  [Read abstract] (PDF, long)  [Read commentary from the CDC HIV/STD/TB Prevention News Update]

From Medscape: Gag protein and p24 capsid subunit would optimize anti-HIV-1 vaccine. HIV-1-specific CD8+ T cell responses to HIV Gag are inversely correlated with viral RNA loads and directly correlated with absolute CD4+ T cell counts. Major histocompatability complex class I presentation of Gag peptides could be essential for an optimally designed HIV-1 vaccine.  [Go to Medscape] Free registration required.  [PubMed abstract]

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