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AIDScience Report: The effectiveness of needle exchange programs: A review of the science and policy By Steffanie A. Strathdee and David Vlahov  [Full text article]  [About AIDScience articles]  [See recent AIDScience articles]

Hot News: Coverage of the 41st ICAAC. From Medscape: 23 HIV-related news reports of the highlights of this week's meeting, authored by Stephen L. Becker, Joseph J. Eron Jr., W. David Hardy, Graeme Moyle, and William A. O'Brien. [Go to Medscape]

New data may explain the loss of T cells in HIV infection. Two new studies have arrived to the conclusion that the decline in T cells in HIV infection is caused by an increase in the rate of CD4+ T cell death, rather than by blocking their production. J. Exp. Med. 194(12):1731-1741, 17 December 2001 [Read abstract]  J. Exp. Med. 194(9):1277-1288, 5 November 2001 [Read abstract]

XIIth International Conference on AIDS and STIs in Africa. Under way in Ouagadougou, Burkina Faso, from 9 to 13 December.  [Go to conference site]

U.S. Public Health Service (PHS)task force recommendations for use of antiretroviral drugs in pregnant HIV-1-infected women for maternal health and interventions to reduce perinatal HIV-1 transmission in the United States. These newly released (December 5) recommendations update the May 4, 2001, guidelines developed by the PHS.  [Go to document (PDF)]

Science Classic Papers: Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR Hadar Feinberg et al., Science 294(5549):2163-2166, 7 December 2001. Cell surface proteins DC-SIGN and DC-SIGNR bind to oligosaccharides that are present on the envelope of HIV, an interaction that strongly promotes viral infection of T cells. An anti-HIV preventative therapy that could interfere with gp120's interaction with these molecules would lower the efficiency of T cell infection at primary sites of infection.  [Free full-text article] | [Other Science Classic Papers]

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